CEM Liberty Lite

Peptide Synthesis Made Fast & Efficient


The Liberty Lite™ Microwave Peptide Synthesizer is an entry level option for the globally recognized Liberty Blue™ technology. The Liberty Lite provides advantages over existing peptide synthesizers with it’s patented use of microwave irradiation during both the deprotection and coupling steps (15 minute cycle times), in situ temperature control, Flex-Add™ delivery system, and efficient solvent usage. Additionally, the system can be upgraded at any time to a complete Liberty Blue system.

Flex-Add Technology

Don’t be limited by fixed sample loops for reagent addition! CEM’s patented Flex-Add™ technology enables a wider range of addition volumes than any other synthesizer. This factory calibrated feature allows infinitely variable volume additions for all amino acid and activator deliveries, and requires no customer calibration after system installation.

In-Situ Fiber Optic Temperature Control

Fast heating requires fast and accurate temperature measurement to prevent thermal overshoot; in-situ temperature measurement provides the most responsive, reliable, and accurate feedback on reaction conditions. The fiber optic probe on the Liberty Lite provides this type of measurement capability and avoids the lag time associated with external IR or thermocouple controls and eliminates the need for routine calibration.

The Microwave Advantage

Microwave energy brings more to peptide synthesis than a rapid change in temperature. Combined with microwave transparent reaction vessels, your reaction, not the vessel, is heated with a uniform, single mode energy distribution. Rapid kinetic movement caused by microwave energy accelerates the reaction and reduces aggregation. The Discover® is the only microwave capable of applying microwave energy to both the deprotection and coupling steps of solid phase peptide synthesis.

Liberty Lite Product Video

CEM Liberty Lite Specifications

Synthesis Scale 0.005-5 mmol
Reaction Vessel Sizes 30- and 125-mL
Chemistry Fmoc only
Activation Method in situ standard activators
Amino Acid Reagents 20
External Bottle Positions 2
Temperature Measurement in situ fiber optic
Fluid Measurement Flex-Add - amino acids, activator, activator base, Timed delivery - main wash, deprotection
Agitation Programmable inert gas bubbling
Waste Container 1 L reservoir with overflow detection Larger sizes available
Controller Laptop with wireless option standard
Optional Features Cleavage module
Reports Printable .pdf file for each method created Log created during each run of every step performed
Power 120V/60Hz or 240V/50Hz
Dimensions 20”W x 18”D x 30”H (51cm x 46 cm x 76 cm)
License The purchase of this instrument includes a grant of limited, non-transferrable, license to utilize this instrument for microwave peptide synthesis using microwave energy for both the coupling and deprotection steps